IN-HOUSE MANUFACTURING | EQUIPMENT | PASS BOXES
"VHP Biodecontamination Pass-Box (Nebulized Hydrogen Peroxide – H₂O₂)
H2O2 Pass Box Automated transfer system with cold vaporized hydrogen peroxide decontamination for material pass-through
MODEL: PBOX H2O2 ALBIAN
Description
The PBOX H2O2 is a biological containment unit designed for airtight material transfer between cleanrooms. Its cold hydrogen peroxide vapor technology provides optimal surface biodecontamination of up to 6 log, reducing the risk of contamination. It features inflatable door gaskets to achieve perfect airtightness and prevent any risk of peroxide leakage.
The unit, built with an AISI 316 chamber, features a continuous airflow system with HEPA H-14 filtration ensuring vertical sweeping. Dampers for efficient management of internal pressure gradients.
Simultaneously, the temperature, humidity, VHP ppm concentration, and saturation ratio are controlled within the chamber.
The unit incorporates an integrated cold vaporized hydrogen peroxide (CVHP) generator, including a 1,000 ml H₂O₂ reservoir with a dosing pump.
It generates vapor at room temperature and offers broad compatibility with materials in the treatment area. This is because its advanced sensors and control software prevent vapor saturation, which can cause condensation and harmful residues.
PBOX H2O2 ALBIAN FEATURES:
- Control and monitoring: The system can be operated locally via the touchscreen or remotely using a tablet, computer, or smartphone through a wired or Wi-Fi connection.
- Flexible operation and smart control: Automated validated cycles with dual operating mode (fast track or disinfection) controlled by PLC, featuring intuitive digital management from touchscreens on both sides.
- Electronic data security: Compliance with 21 CFR Part 11 and GMP Annex 11 requirements
- Full plant integration: Technology ready to connect with your facility’s centralized systems (BMS/SCADA).
- Advanced filtration: Equipped with an absolute HEPA H14 filtration system to guarantee GRADE B at all times.
- Hygienic design: AISI 316 stainless steel interior with mirror polish and rounded corners to facilitate immediate cleaning
Sectors and Regulatory Compliance
Designed and manufactured to pass the most demanding international audits, it is an essential application in classified areas according to ISO 14644, GMP, FDA, BRC, and IPS within the following sectors:
- Pharmaceutical and Biotechnology Industry.
- Veterinary Pharmaceutical Industry
- High-security food industry.
- Biosafety Research Centers
Main advantages of the ALBIAN H2O2 PBOX
- Maximum biological safety:
Automated cold vaporized hydrogen peroxide (CVHP) cycles ensuring fast, safe, and total microbiological elimination. Uses hydrogen peroxide at concentrations between 30% and 50% as a biocide to generate a micro-condensation-free vapor capable of destroying up to 99.9999% (6 log) of viruses, bacteria, fungi, and bacterial spores. Thanks to its adaptive control, it is possible to use lower concentrations of hydrogen peroxide.
- Smart operator protection: Automatic door locking system with indicator lights that prevents any opening until the chamber concentration drops below 1 ppm.
- Pharmaceutical-grade airtightness: Flush doors with advanced inflatable gaskets, requiring no external compressed air connection. Guaranteed equipment airtightness. Class 3: 1.0% volume loss per hour (according to ISO 10648 and ISO 14644-7), preventing hydrogen peroxide contamination outside the equipment.
- Material compatibility: Material compatibility: Thanks to the unit generating vapor at room temperature and utilizing a control system that continuously monitors relative saturation, oversaturation and micro-condensation are prevented. This ensures that sensitive electronic components, fabrics, and optical equipment do not degrade.
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What are the stages of the VHP decontamination cycle, and how is it ensured that the residual peroxide level is safe?
The automated cold vaporized hydrogen peroxide (VHP – H₂O₂) biodecontamination cycle consists of four consecutive key stages
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Dehumidification: Preparation and drying of the air inside the chamber.
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Injection: Introduction of the vaporized peroxide through strategic nozzles.
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Biodecontamination: Maintenance of the required concentration to guarantee an optimal microbiological reduction of up to 6 log.
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Final aeration: Forced ventilation through a continuous airflow and vertical sweep to safely reduce the peroxide concentration below 1 ppm before allowing the doors to open.
What variables and controlled environment are monitored inside the chamber during the cycle?
To ensure maximum repeatability, safety, and efficacy of the disinfection process, the system monitors and controls the following critical variables inside the chamber in real-time and digitally: internal pressure, temperature, relative humidity, peroxide concentration (ppm), and VHP saturation level.
How is the vaporized hydrogen peroxide (VHP) generated, and how is it injected into the equipment's chamber?
The PBOX H2O2 incorporates a 1,500 ml peroxide safety tank with smart level control in its lower technical area. Utilizing a cold nebulization system backed by high-precision metering pumps, the peroxide is injected and homogeneously distributed into the chamber through six diffusion nozzles (strategically arranged with three on each side).
How are the airtightness and hermeticity of the chamber guaranteed during the VHP nebulization process?
Airtightness is ensured through a flush-mounted door system equipped with inflatable seals. Additionally, the equipment features airtight shut-off dampers on both the supply and exhaust of filtered air. The entire process is backed by a pressure sensor that constantly monitors absolute containment inside.
Is the PBOX H2O2 control system integrable with the plant's centralized systems?
Yes, Albian’s PLC-based control system comes natively ready for seamless connectivity and full integration with the centralized BMS (Building Management System) or SCADA management systems of your pharmaceutical or biotechnological facility.
How is the maintenance of the components and the refilling of the H2O2 tank carried out?
The hygienic and functional design of the equipment facilitates technical maintenance tasks:
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Filter replacement: The replacement of the H14 HEPA supply filter is carried out comfortably and safely directly from inside the chamber.
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Maintenance and refilling: The equipment features technical access doors in the lower area that allow ergonomic access for inspection and safe refilling of the peroxide tank.
Projects
Facilities for a company focused on the production of DNA for advanced therapies
Turnkey project executed in several phases with excellent coordination and compliance with deadlines.
Autovaccine production plant
Complete project adapted to the security and containment needs of the client.
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